- Sook-Yin Lee & Dylan Gamble
- Soupcans
- Spacecraft 7
- Speedway
- Speedy Ortiz
- Spek Won
- Spiral Beach
- Spitfires & Mayflowers
- Spitfires and Mayflowers
- Spoils
- Spy Machine 16
- Square Root of Margaret
- SS Cardiacs
- Status/Non-Status
- Steamboat
- Stefana Fratila
- Stella
- Steve & The Asthma Attacks
- Steve Shiffman & The Land of No
- Steven Lambke
