Picastro began in Toronto in 1998 with Liz Hysen, Stephanie Vittas and Kurt Newman. Since then, the band has continued in many forms with its current band members consisting of Liz Hysen, Nick Storring, Germaine Liu and Matthew Ramolo.

Picastro has toured extensively over the past 10 years in North America and Europe. Picastro has appeared on BBC radio, VPRO (Dutch national radio) and the venerable WFMU.

Picastro has also played a number of festivals including:
SXSW (Austin), CMJ (NYC), Incubate (Netherlands), Rhaaa Lovely (Belgium), Žedno Uho (Croatia), Tanned Tin (Spain),  Suoni Per il Popolo (Montreal) and NXNE (Toronto).

The band has toured or played shows with:
Scout Niblett, Nadja, Cerberus Shoal, Xiu Xiu, Devendra Banhart, Marissa Nadler, Dwayne Sodahberk, Broken Social Scene and many other wonderful artists.